Clinical Characteristics of Primary Vitreoretinal Lymphoma in an Indian Population. (3rd September 2017)

• Record Type: Journal Article
• Authors: Mahajan, Sarakshi; Nijhawan, Raje; Rajwanshi, Aravind; Karkhur, Samendra; Mulkutar, Samyak; Dogra, Mohit; Lal, Vivek; Gupta, Vishali; Gupta, Amod
• Is Part Of: Ocular immunology and inflammation. Volume 25:Number 5(2017)
• Page Start: 638
• Page End: 643
• Publication Date: 2017-09-03
• Subjects: Primary vitreoretinal lymphoma -- uveitis -- intravitreal methotrexate -- primary CNS lymphoma -- subretinal deposits; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2016.1139731
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : Primary vitreoretinal lymphomas (PVRL) pose a major diagnostic challenge, especially in the countries with a high prevalence of infectious variety of uveitis. The present study aims to report the clinical characteristics and diagnostic difficulties in patients with PVRL in an Indian Population. Methods : Retrospective chart reviews of 12 patients with a diagnosis of PVRL. Results : The study included 6 men and 6 women, with a mean age of 55.66 ± 8.76 years. All had bilateral disease. The clinical signs included anterior uveitis (12 eyes; 50.0%); vitritis (18 eyes; 75%); vitreous clumps (16 eyes; 66.6%); subretinal deposits (11 eyes; 45.8%); retinal vasculitis (6 eyes; 25%); and optic disc swelling (2 eyes; 8.3%). The most commonly mistaken diagnosis was intraocular tuberculosis. The intraocular lesions responded to multiple intravitreal methotrexate injections. Conclusions : PVRL in India was likely to be mistaken for an infectious variety of uveitis. A high index of suspicion and thorough clinical examination is necessary to make the diagnosis.