(Putative) sex differences in neuroimmune modulation of memory. Issue 1 (7th November 2016)

• Record Type: Journal Article
• Authors: Tronson, Natalie C.; Collette, Katie M.
• Other Names: Cahill Larry guestEditor.
• Is Part Of: Journal of neuroscience research. Volume 95:Issue 1/2(2017)
• Page Start: 472
• Page End: 486
• Publication Date: 2016-11-07
• Subjects: learning and memory -- cytokines -- females -- microglial activation -- neurogenesis -- astrocytes -- synaptic plasticity; Neurobiology -- Periodicals; 612
• DOI: 10.1002/jnr.23921
• Languages: English
• ISSNs: 0360-4012

Abstract

Abstract : The neuroimmune system is significantly sexually dimorphic, with sex differences evident in the number and activation states of microglia, in the activation of astrocytes, and in cytokine release and function. Neuroimmune cells and signaling are now recognized as critical for many neural functions throughout the life span, including synaptic plasticity and memory function. Here we address the question of how cytokines, astrocytes, and microglia contribute to memory, and specifically how neuroimmune modulation of memory differentially affects males and females. Understanding sex differences in both normal memory processes and dysregulation of memory in psychiatric and neurological disorders is critical for developing treatment and preventive strategies for memory disorders that are effective for both men and women. © 2016 Wiley Periodicals, Inc.