Microwave‐Assisted Suzuki‐Miyaura Cross Coupling using Nickel as Catalyst to Rapidly Access to 3‐Arylazetidine. Issue 28 (2nd October 2017)

• Record Type: Journal Article
• Authors: Dequirez, Geoffroy; Bourotte, Marilyne; Porras de Francisco, Esther; Remuiñan Blanco, Modesto J.; Déprez, Benoit; Willand, Nicolas
• Is Part Of: ChemistrySelect. Volume 2:Issue 28(2017)
• Page Start: 8841
• Page End: 8846
• Publication Date: 2017-10-02
• Subjects: 3-Arylazetidine -- Heterocycles -- Microwave irradiation -- Nickel catalysis -- Suzuki-Miyaura cross coupling; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201702101
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The efficient synthesis of 3‐arylazetidine derivatives is reported using a Nickel‐catalyzed Suzuki‐Miyaura coupling between arylboronic acids and a N‐BOC‐protected 3‐iodoazetidine under microwave irradiation. The reaction tolerates a great range of substituents such as electrodonating and electron withdrawing groups opening the field of the diversity especially in the context of structure activity relationship studies. Abstract : Suzuki‐Miyaura coupling between arylboronic acids and protected 3‐iodoazetidine under microwave irradiation provide the rapid access to a wide range of 3‐arylazetidine derivatives. This reaction is catalyzed with Nickel catalyst and under basic conditions.