Heterotopic Abdominal Rat Heart Transplantation as a Model to Investigate Volume Dependency of Myocardial Remodeling. Issue 3 (March 2017)

• Record Type: Journal Article
• Authors: Benke, Kálmán; Sayour, Alex Ali; Mátyás, Csaba; Ágg, Bence; Németh, Balázs Tamás; Oláh, Attila; Ruppert, Mihály; Hartyánszky, István; Szabolcs, Zoltán; Radovits, Tamás; Merkely, Béla; Szabó, Gábor
• Is Part Of: Transplantation. Volume 101:Issue 3(2017)
• Publication Date: 2017-03
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/TP.0000000000001585
• Languages: English
• ISSNs: 0041-1337

Abstract

Abstract : Abstract: Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the experimental studies on rat heart transplantation to illustrate changes that occur to the myocardium due to volume unloading. We divided the literature based on whether normal or failing rat heart models were used. This analysis may provide a basis to understand the physiological effects of mechanical circulatory support therapy. Abstract : To understand the effects of mechanical unloading, the authors summarize the findings of volume-dependent myocardial remodelling in the latest experimental studies on rat heart transplantation models.