Facile One‐Pot Multi‐Component Synthesis of Spirooxindoles and 3, 3'‐Disubstituted Oxindoles via sp3 C‐H Activation/Functionalization of Azaarenes. Issue 28 (9th October 2017)

• Record Type: Journal Article
• Authors: Pathan, Mohsinkhan Y.; Chavan, Santosh S.; Shaikh, Taufeekaslam M. Y.; Thorat, Shridhar H.; Gonnade, Rajesh G.; Mulla, Shafeek A. R.
• Is Part Of: ChemistrySelect. Volume 2:Issue 28(2017)
• Page Start: 9147
• Page End: 9152
• Publication Date: 2017-10-09
• Subjects: 3, 3'-disubstituted oxindoles -- silica-supported dodecatungstophosphoric acid (DTP/SiO2) catalyst -- sp3 C−H activation/functionalization -- spirooxindoles -- azaarenes; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201701507
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A novel one‐pot multicomponent reaction (MCR) protocol has been demonstrated for the first time for sustainable and facile synthesis of spirooxindoles and 3, 3'‐disubstituted oxindoles in an excellent yield via sp 3 C−H activation/functionalization of 2‐methyl azaarenes and (2‐azaaryl)methanes with isatin, active methylene compounds using eco‐friendly heterogeneous, reusable silica‐supported dodecatungstophosphoric acid (DTP/SiO2 ) catalyst. Abstract : A novel one‐pot multicomponent reaction protocol has been demonstrated first time using eco‐friendly heterogeneous, reusable silica‐supported dodecatungstophosphoric acid (DTP/SiO2 ) catalyst for sustainable and facile synthesis of spirooxindoles and 3, 3 ' ‐disubstituted oxindoles via sp 3 C−H functionalization of azaarenes.