Persistent Photoconductivity, Nanoscale Topography, and Chemical Functionalization Can Collectively Influence the Behavior of PC12 Cells on Wide Bandgap Semiconductor Surfaces. Issue 24 (2nd May 2017)

• Record Type: Journal Article
• Authors: Snyder, Patrick J.; Kirste, Ronny; Collazo, Ramon; Ivanisevic, Albena
• Is Part Of: Small. Volume 13:Issue 24(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-05-02
• Subjects: gallium nitride -- PC12 cells -- persistent photoconductivity -- roughness -- surface functionalization; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201700481
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Wide bandgap semiconductors such as gallium nitride (GaN) exhibit persistent photoconductivity properties. The incorporation of this asset into the fabrication of a unique biointerface is presented. Templates with lithographically defined regions with controlled roughness are generated during the semiconductor growth process. Template surface functional groups are varied using a benchtop surface functionalization procedure. The conductivity of the template is altered by exposure to UV light and the behavior of PC12 cells is mapped under different substrate conductivity. The pattern size and roughness are combined with surface chemistry to change the adhesion of PC12 cells when the GaN is made more conductive after UV light exposure. Furthermore, during neurite outgrowth, surface chemistry and initial conductivity difference are used to facilitate the extension to smoother areas on the GaN surface. These results can be utilized for unique bioelectronics interfaces to probe and control cellular behavior. Abstract : A wide bandgap semiconductor material, GaN, which exhibits persistent photocurrent after UV light exposure is used to alter the adhesion of PC12 cells in conjunction with substrate surface roughness and chemical functionalization. The synergy among these three parameters is used to direct the placement of the cells during in vitro experiments.