Polycystic kidney disease is significantly associated with dementia risk. (3rd October 2017)

• Record Type: Journal Article
• Authors: Yu, Tung-Min; Chuang, Ya-Wen; Sun, Kuo-Ting; Yu, Mei-Ching; Kung, Shiang-Cheng; Lee, Brian K.; Huang, Shih-Ting; Chen, Cheng-Hsu; Lin, Cheng-Li; Kao, Chia-Hung
• Is Part Of: Neurology. Volume 89:Number 14(2017)
• Publication Date: 2017-10-03
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000004434
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: Data on the risk of neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD), in patients with polycystic kidney disease (PKD) are lacking. Methods: A total of 4, 229 patients who were aged ≥20 years and had received a diagnosis of PKD were included in the PKD cohort. For each PKD case identified, 1 participant aged ≥20 years without a history of PKD, dementia, or PD was selected from the comparison cohort. For each patient with PKD, the corresponding controls were selected 1:1 on the basis of the nearest propensity score calculated using logistic regression. Results: The incidence density rates of dementia were 4.31 and 2.50 per 1, 000 person-years in the PKD and control cohorts, respectively. A 2.04-fold higher risk of dementia was observed in patients with PKD than in controls (adjusted hazard ratio [aHR] 2.04; 95% confidence interval [CI] 1.46–2.85). Regarding the risk of different dementia subtypes, including AD and vascular dementia (VaD), the aHR for AD and presenile dementia was 2.71 (95% CI 1.08–6.75) and that for VaD was 0.90 (95% CI 0.43–1.87) in patients with PKD compared with controls, after adjustment for age, sex, and comorbidities. Compared with controls, the risk of PD increased by 1.78-fold (95% CI 1.14–2.79) in patients with PKD. Conclusions: In clinical practice, health care professionals should be aware of the risk of neurodegenerative diseases in patients with PKD.