Inflammatory and multiple hepatocellular adenoma are associated with a higher BMI. Issue 10 (October 2017)

• Record Type: Journal Article
• Authors: Bröker, Mirelle E.E.; Gaspersz, Marcia P.; Klompenhouwer, Anne J.; Hansen, Bettina E.; Terkivatan, Turkan; Taimr, Pavel; Dwarkasing, Roy; Thomeer, Maarten G.J.; de Man, Robert A.; IJzermans, Jan N.M.
• Is Part Of: European journal of gastroenterology & hepatology. Volume 29:Issue 10(2017:Oct.)
• Publication Date: 2017-10
• Subjects: adenoma -- disease management -- liver cell -- liver diseases -- liver -- obesity; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Digestive organs -- Diseases; Liver -- Diseases; Periodicals; 616.33
• DOI: 10.1097/MEG.0000000000000930
• Languages: English
• ISSNs: 0954-691X

Abstract

Abstract : Aim: To identify patient and lesion characteristics associated with the occurrence of single or multiple hepatocellular adenoma (HCA). Patients and methods: Using a tertiary centre database, we retrospectively collected information on patient and lesion characteristics, management and follow-up of all patients with HCA included between 2001 and 2016. Patients were classified into three groups; patients with a single HCA, 2–9 HCA and at least 10 HCA. Results: A total of 458 patients were diagnosed with HCA, including 121 (26.4%) with single HCA, 235 (51.3%) with 2–9 HCA and 102 (22.3%) with at least 10 HCA. Significant differences in the mean BMI were found, with the highest BMI in patients with more than 10 HCA ( P <0.05). The mean BMI was significantly higher in patients with inflammatory HCA compared with steatotic HCA (31 vs. 26, respectively, P <0.05). Steatotic HCA were more often single lesions (22/55, 40%), whereas patients with inflammatory HCA were often diagnosed with multiple lesions (122/166, 73%). Conclusion: Our series show a significantly higher BMI and frequency of inflammatory HCA in patients with multiple HCA compared with single HCA.