Necrotizing Infundibular Crystalline Folliculitis (NICF) Induced by Anti-Tumoral Therapies: Report of 2 Cases. (October 2017)

• Record Type: Journal Article
• Authors: Fattouh, Kinda; Collet-Benzaquen, Diane; Provensal, Anne M.; Desseigne, Françoise; Castillo, Christine; Combemale, Patrick; de la Fouchardière, Arnaud
• Is Part Of: American journal of dermatopathology. Volume 39:Number 10(2017)
• Publication Date: 2017-10
• Subjects: necrotizing infundibular crystalline folliculitis -- NICF -- drug induced dermatitis -- EGFR inhibitor -- VEGF inhibitor; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000000743
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: Necrotizing Infundibular Crystalline Folliculitis (NICF) is rare entity of unknown pathogenesis presenting as follicular crystalline papules arising in seborrheic areas. We report 2 cases of NICF in patients under targeted therapy for metastatic adenocarcinoma. In one case, the lesions reappeared cyclically every 3 weeks after each injection and in the other case, lesions persisted until disruption of the continuous oral therapy. Punch-biopsies demonstrated folliculitis with a plugging crystalline material associated with either bacteria or yeast. These are the first descriptions of drug-induced NICF.