Very Long-term Sequelae After Nonradical Surgery Combined With Brachytherapy in an Infant With a Chemotherapy-resistant Rhabdomyosarcoma of the Tongue. Issue 7 (October 2017)

• Record Type: Journal Article
• Authors: van Rijswijk, Petra M.; van den Heuvel-Eibrink, Marry M.; van den Akker, Erica L.T.; Slagter, Cleo; Lequin, Maarten H.; Aarsen, Femke K.; van Atteveld, Jenneke E.; Wagner, Anja; van Grotel, Martine
• Is Part Of: Journal of pediatric hematology/oncology. Volume 39:Issue 7(2017)
• Publication Date: 2017-10
• Subjects: rhabdomyosarcoma -- tongue -- brachytherapy -- long-term sequelae -- infant -- Gorlin syndrome; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000935
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : In 2003, van Grotel and colleagues reported an infant suffering a chemotherapy-resistant eRMS of the tongue, that was treated with subtotal tumor resection and brachytherapy after major medical ethical discussions. As no long-term sequelae of such a procedure have been described, perspectives were uncertain at that time. Now, after 15 years, we describe hypoplasia of the mandibula, compromised dentation, osteopenia, neuropsychological deficits, and moderate speech impairment as the most prominent late effects. Also, mandibular cysts and basal cell carcinomas in the irradiated area, eventually led to the diagnosis Gorlin syndrome. Abstract : Supplemental Digital Content is available in the text.