Biopsy-Proven Diffuse Mediastinal Prostate Cancer Metastases Negative on 18F-Fluorocholine, Diagnosed on 68Ga-PSMA and 18F-PSMA PET/CT. (October 2017)

• Record Type: Journal Article
• Authors: Chaussé, Guillaume; Niazi, Tamim; Abikhzer, Gad Solomon; Probst, Stephan Michael
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 10(2017)
• Publication Date: 2017-10
• Subjects: 18F-fluorocholine -- 18F-PSMA -- 68Ga-PSMA -- false negative -- FCH -- metastasis -- mediastinum -- PET/CT -- prostate cancer -- PSMA; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001766
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 72-year-old man with prostate cancer (stage T3b, Gleason score 7) treated by radical prostatectomy was found to have biochemical failure (prostate-specific antigen 8.5 ng/mL) and a suspicious growing nodularity at the left prostate bed on MRI. 18 F-fluorocholine PET/CT failed to demonstrate any site of uptake suggestive of malignancy. A bone scan did exclude bone metastases. 68 Ga-PSMA PET/CT revealed various positive lymph nodes in the supraclavicular, mediastinal, and hilar regions. This was confirmed on 18 F-DCFPyl PET/CT, with the addition of a suspicious right axillary lymph node. Mediastinal biopsy confirmed metastatic prostate cancer.