Thyroid Metastasis as First Manifestation of a Colon Adenocarcinoma With KRAS Mutation: Usefulness of 18F-FDG PET/CT. (October 2017)

• Record Type: Journal Article
• Authors: Lecumberri, Beatriz; López, Elena; Coronado, Mónica; Rodado, Sonia; Castelo, Beatriz
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 10(2017)
• Publication Date: 2017-10
• Subjects: 18F-FDG PET/CT -- colon adenocarcinoma -- KRAS mutation -- thyroid metastasis; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001776
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: The synchronous diagnosis of a thyroid metastasis and of the primary colon adenocarcinoma that produces it is very rare, with only 5 cases reported to date, all of them treated with thyroid surgery showing a mean survival of 7 months. An 18 F-FDG PET/CT in an asymptomatic 74-year-old woman with a thyroid cytology suggestive of malignancy but uncertain about the origin of the tumor revealed an stage IV colon adenocarcinoma with KRAS mutation and multiple metastasis (thyroid, lung, and liver). A prompt therapeutic planning with chemotherapy allowed 21 months of survival.