Liver Transplantation in the Obese Cirrhotic Patient. Issue 10 (October 2017)

• Record Type: Journal Article
• Authors: Spengler, Erin K.; O'Leary, Jacqueline G.; Te, Helen S.; Rogal, Shari; Pillai, Anjana A.; Al-Osaimi, Abdullah; Desai, Archita; Fleming, James N.; Ganger, Daniel; Seetharam, Anil; Tsoulfas, Georgios; Montenovo, Martin; Lai, Jennifer C.
• Is Part Of: Transplantation. Volume 101:Issue 10(2017)
• Publication Date: 2017-10
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/TP.0000000000001794
• Languages: English
• ISSNs: 0041-1337

Abstract

Abstract : Abstract: Despite the rapidly increasing prevalence of obesity in the transplant population, the optimal management of obese liver transplant candidates remains undefined. Setting strict body mass index cutoffs for transplant candidacy remains controversial, with limited data to guide this practice. Body mass index is an imperfect measure of surgical risk in this population, partly due to volume overload and variable visceral adiposity. Weight loss before transplantation may be beneficial, but it remains important to avoid protein calorie malnutrition and sarcopenia. Intensive lifestyle modifications appear to be successful in achieving weight loss, though the durability of these interventions is not known. Pretransplant and intraoperative bariatric surgeries have been performed, but large randomized controlled trials are lacking. Traditional cardiovascular comorbidities are more prevalent in obese individuals and remain the basis for pretransplant cardiovascular evaluation and risk stratification. The recent US liver transplant experience demonstrates comparable patient and graft survival between obese and nonobese liver transplant recipients, but obesity presents important medical and surgical challenges during and after transplant. Specifically, obesity is associated with an increased incidence of wound infections, wound dehiscence, biliary complications and overall infection, and confers a higher risk of posttransplant obesity and metabolic syndrome-related complications. In this review, we examine current practices in the obese liver transplant population, offer recommendations based on the currently available data, and highlight areas where additional research is needed. Abstract : An international multi-author review addresses the issues associated with liver transplantation in the obese cirrhotic patient. While overall survival is comparable to nonobese transplants, numerous medical and technical considerations are present.