An Integrated Experimental-Modelling Approach of Mesenchymal Stem Cell Bioprocess towards Osteogenic Differentiation. Issue 1 (July 2017)

• Record Type: Journal Article
• Authors: Győrgy, Romuald; Klontzas, Michail E.; Kostoglou, Margaritis; Panoskaltsis, Nicki; Georgiadis, Michael C.; Mantalaris, Athanasios
• Is Part Of: IFAC-PapersOnLine. Volume 50:Issue 1(2017)
• Page Start: 9877
• Page End: 9882
• Publication Date: 2017-07
• Subjects: Mesenchymal -- MSC -- cord blood -- stem cells -- osteogenesis -- modelling -- identification -- cell cycle -- differentiation -- population balance; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2017.08.1603
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: The use of mesenchymal stem cells (MSCs) for artificial bone graft production can meet the increasing demands of the tissue engineering market and provide off-the-shelf, safe and high quality material for grafting procedures. Herein, we present an integrated-modelling approach to describe the osteogenic differentiation of MSCs based on gene expression, cell cycle dynamics, and population balance equations.