Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors*. Issue 1 (July 2017)

• Record Type: Journal Article
• Authors: St. John, Peter C.; Crowley, Michael F.; Bomble, Yannick J.
• Is Part Of: IFAC-PapersOnLine. Volume 50:Issue 1(2017)
• Page Start: 9883
• Page End: 9888
• Publication Date: 2017-07
• Subjects: Fermentation processes -- Open-loop control systems -- Optimal control -- nonlinear programming; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2017.08.1605
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: A key step towards the development of an integrated biorefinery is the screening of economically viable processes, which depends sharply on the yields and productivities that can be achieved by an engineered microorganism. In this study, we extend an earlier method which used dynamic optimization to find the maximum theoretical productivity of batch cultures to explicitly include fed-batch bioreactors. In addition to optimizing the intracellular distribution of metabolites between cell growth and product formation, we calculate the optimal control trajectory of feed rate versus time. We further analyze how sensitive the productivity is to substrate uptake and growth parameters.