Treatment restrictions in patients with severe stroke are associated with an increased risk of death. (September 2017)

• Record Type: Journal Article
• Authors: Geurts, Marjolein; de Kort, Floor AS; de Kort, Paul LM; van Tuijl, Julia H; van Thiel, Ghislaine JMW; Kappelle, L Jaap; van der Worp, H Bart
• Is Part Of: European stroke journal. Volume 2:Number 3(2017)
• Page Start: 244
• Page End: 249
• Publication Date: 2017-09
• Subjects: Stroke -- ethics -- mortality -- survival; Cerebrovascular disease -- Periodicals; 616.8005
• DOI: 10.1177/2396987317704546
• Languages: English
• ISSNs: 2396-9873

Abstract

Introduction: Treatment restrictions in the first 2 days after intracerebral haemorrhage have been independently associated with an increased risk of early death. It is unknown whether these restrictions also affect mortality if these are installed several days after stroke onset. Patients and methods: Sixty patients with severe functional dependence at day 4 after ischaemic stroke or intracerebral haemorrhage were included in this prospective two-centre cohort study. The presence of treatment restrictions was assessed at the day of inclusion. Information about mortality, functional outcome (modified Rankin scale) score and quality of life (visual analogue scale) was recorded 6 months after stroke onset. Poor outcome was defined as modified Rankin scale >3. Satisfactory quality of life was defined as visual analogue scale ≥ 60. Results: At 6 months, 30 patients had died, 19 survivors had a poor functional outcome and 9 patients had a poor quality of life. Treatment restrictions were independently associated with mortality at 6 months (adjusted relative risk, 1.30; 95% confidence interval, 1.06–1.59; p = 0.01), but not with functional outcome. Discussion: Our findings were observed in 60 selected patients with severe stroke. Conclusion: The instalment of treatment restrictions by itself may increase the risk of death after stroke, even if the first 4 days have passed. In future stroke studies, this potential confounder should be taken into account. Quality of life was satisfactory in the majority of the survivors, despite considerable disability.