Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy. Issue 11 (9th October 2017)

• Record Type: Journal Article
• Authors: Bezzina, Oriana M.; Gallagher, Peter; Mitchell, Sheryl; Bowman, Simon J.; Griffiths, Bridget; Hindmarsh, Victoria; Hargreaves, Ben; Price, Elizabeth J.; Pease, Colin T.; Emery, Paul; Lanyon, Peter; Bombardieri, Michele; Sutcliffe, Nurhan; Pitzalis, Costantino; Hunter, John; Gupta, Monica; McLaren, John; Cooper, Anne M.; Regan, Marian; Giles, Ian P.; Isenberg, David A.; Saravanan, Vadivelu; Coady, David; Dasgupta, Bhaskar; McHugh, Neil J.; Young‐Min, Steven A.; Moots, Robert J.; Gendi, Nagui; Akil, Mohammed; MacKay, Kirsten; Ng, W. Fai; Robinson, Lucy J.;
• Other Names: Bacabac Elalaine C investigator.; Moots Robert investigator.; Chakravarty Kuntal investigator.; Lamabadusuriya Shamin investigator.; Pitzalis Constantino investigator.; Adeniba Rashidat investigator.; Hamburger John investigator.; Richards Andrea investigator.; Rauz Saaeha investigator.; Brailsford Sue investigator.; Logan Joanne investigator.; Mulherin Diarmuid investigator.; Andrews Jacqueline investigator.; McManus Alison investigator.; Pease Colin investigator.; Booth Alison investigator.; Dimitroulas Theodoros investigator.; Kadiki Lucy investigator.; Kaur Daljit investigator.; Kitas George investigator.; Lloyd Mark investigator.; Moore Lisa investigator.; Gordon Esther investigator.; Lawson Cathy investigator.; Stirton Lesley investigator.; Ortiz Gill investigator.; Price Elizabeth investigator.; Clunie Gavin investigator.; Rose Ginny investigator.; Cuckow Sue investigator.; Knight Susan investigator.; Symmons Deborah investigator.; Jones Beverley investigator.; Al‐Ali Shereen investigator.; Carr Andrew investigator.; Collins Katherine investigator.; Corbett Ian investigator.; Downie Christine investigator.; Edgar Suzanne investigator.; Carrozzo Marco investigator.; Figuereido Francisco investigator.; Foggo Heather investigator.; Humphreys Claire investigator.; James Katherine investigator.; Lendrem Dennis investigator.; Locke James investigator.; Macleod Iain investigator.; Mawson Philip investigator.; Stocks Philip investigator.; Tarn Jessica investigator.; Jones Adrian investigator.; Muir Alice investigator.; White Paula investigator.; Young‐Min Steven investigator.; Pugmire Susan investigator.; Vadivelu Saravanan investigator.; Cooper Annie investigator.; Watkins Marianne investigator.; Field Anne investigator.; Kaye Stephen investigator.; Mewar Devesh investigator.; Medcalf Patricia investigator.; Tomlinson Pamela investigator.; Whiteside Debbie investigator.; McHugh Neil investigator.; Pauling John investigator.; James Julie investigator.; Olaitan Nike investigator.; McDermott Jayne investigator.; Godia Olivia investigator.; Kidd Elizabeth investigator.; Palmer Lynne investigator.; Katsande Victoria investigator.; Long Pamela investigator.; Li Charles investigator.; Chandra Usha investigator.; Fedele Stefano investigator.; Ferenkeh‐Koroma Ada investigator.; Giles Ian investigator.; Isenberg David investigator.; Maconnell Helena investigator.; Porter Stephen investigator.; Allcoat Paul investigator.;
• Is Part Of: Arthritis care & research. Volume 69:Issue 11(2017:Nov.)
• Page Start: 1714
• Page End: 1723
• Publication Date: 2017-10-09
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/acr.23165
• Languages: English
• ISSNs: 2151-464X

Abstract

Abstract : Objective: To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity. Methods: Archive data from the UK Primary Sjögren's Syndrome Registry (n = 688) were used. Patients were classified on a scale from −5 (stoical) to +5 (sensitive) depending on the degree of discrepancy between their objective and subjective symptoms classes. Sensitivity scores were correlated with demographic variables, disease‐related factors, and symptoms of pain, fatigue, anxiety, and depression. Results: Patients were on average relatively stoical for both types of dryness symptoms (mean ± SD ocular dryness −0.42 ± 2.2 and −1.24 ± 1.6 oral dryness). Twenty‐seven percent of patients were classified as sensitive to ocular dryness and 9% to oral dryness. Hierarchical regression analyses identified the strongest predictor of ocular dryness sensitivity to be self‐reported pain and that of oral dryness sensitivity to be self‐reported fatigue. Conclusion: Ocular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sjögrenʼs syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies.