Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?. (1st January 2017)

• Record Type: Journal Article
• Authors: Köhler, Stephan; Ouahrani-Bettache, Safia; Winum, Jean-Yves
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 32:Number 1(2017)
• Page Start: 683
• Page End: 687
• Publication Date: 2017-01-01
• Subjects: Metalloenzyme -- anti-infective agents -- carbonic anhydrase -- Brucella -- inhibitors; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2017.1295451
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two β-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the causative agent of brucellosis or Malta fever. These enzymes have been investigated in detail and a wide range of classical aromatic and heteroaromatic sulfonamides as well as carbohydrate-based compounds have been found to inhibit selectively and efficiently Brucella suis carbonic anhydrases. Inhibition of these metalloenzymes constitutes a novel approach for the potential development of new anti- Brucella agents. This review aims at discussing the recent literature on this topic.