Analysis of air-, moisture- and solvent-sensitive chemical compounds by mass spectrometry using an inert atmospheric pressure solids analysis probe. Issue 1 (February 2018)

• Record Type: Journal Article
• Authors: Mosely, Jackie A; Stokes, Peter; Parker, David; Dyer, Philip W; Messinis, Antonis M
• Is Part Of: European journal of mass spectrometry. Volume 24:Issue 1(2018)
• Page Start: 74
• Page End: 80
• Publication Date: 2018-02
• Subjects: Mass spectrometry -- inert atmospheric pressure solids analysis probe ionisation -- analysis -- moisture- and/or air-sensitive chemicals; Mass spectrometry -- Periodicals; Mass Spectrometry; Mass spectrometry; Periodicals; Periodicals; 543.6505
• DOI: 10.1177/1469066717732286
• Languages: English
• ISSNs: 1469-0667

Abstract

A novel method has been developed that enables chemical compounds to be transferred from an inert atmosphere glove box and into the atmospheric pressure ion source of a mass spectrometer whilst retaining a controlled chemical environment. This innovative method is simple and cheap to implement on some commercially available mass spectrometers. We have termed this approach inert atmospheric pressure solids analysis probe ( i ASAP) and demonstrate the benefit of this methodology for two air-/moisture-sensitive chemical compounds whose characterisation by mass spectrometry is now possible and easily achieved. The simplicity of the design means that moving between i ASAP and standard ASAP is straightforward and quick, providing a highly flexible platform with rapid sample turnaround.