Plasma H2S predicts coronary artery lesions in children with Kawasaki disease. Issue 5 (29th May 2015)

• Record Type: Journal Article
• Authors: Sun, Yan; Yuan, Yue; Yan, Hui; Wan, Hong; Li, Xueying; Chen, Siyao; Li, Hongxia; Tang, Chaoshu; Du, Junbao; Liu, Guiying; Jin, Hongfang
• Is Part Of: Pediatrics international. Volume 57:Issue 5(2015)
• Page Start: 840
• Page End: 844
• Publication Date: 2015-05-29
• Subjects: hydrogen sulfide -- inflammation -- Kawasaki disease -- vasculitis; Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.12631
• Languages: English
• ISSNs: 1328-8067

Abstract

Abstract: Background: The aim of this study was to determine whether plasma hydrogen sulfide (H2 S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD). Methods: A prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2 S was analyzed at the acute stage. Plasma H2 S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out. Results: Plasma H2 S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2 S at acute stage compared with the non‐CAL patients. A plasma H2 S cut‐off of 31.2 µmol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2 S to predict CAL in KD children. Conclusion: Plasma H2 S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.