Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA). Issue 5 (20th May 2016)

• Record Type: Journal Article
• Authors: Kim, Daniel Seung; Li, Yatong K.; Bell, Griffith A.; Burt, Amber A.; Vaisar, Tomas; Hutchins, Patrick M.; Furlong, Clement E.; Otvos, James D.; Polak, Joseph F.; Arnan, Martinson Kweku; Kaufman, Joel D.; McClelland, Robyn L.; Longstreth, W. T.; Jarvik, Gail P.
• Is Part Of: Journal of the American Heart Association. Volume 5:Issue 5(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-05-20
• Subjects: antioxidant -- carotid intima media thickening -- cerebrovascular disease -- high‐density lipoprotein cholesterol -- high‐density lipoprotein particle concentration -- paraoxonase 1; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.115.002977
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Recent studies have failed to establish a causal relationship between high‐density lipoprotein cholesterol levels (HDL‐C) and cardiovascular disease (CVD), shifting focus to other HDL measures. We previously reported that smaller/denser HDL levels are protective against cerebrovascular disease. This study sought to determine which of small+medium HDL particle concentration (HDL‐P) or large HDL‐P was more strongly associated with carotid intima‐media thickening (cIMT) in an ethnically diverse cohort. Methods and Results: In cross‐sectional analyses of participants from the Multi Ethnic Study of Atherosclerosis (MESA), we evaluated the associations of nuclear magnetic resonance spectroscopy–measured small+medium versus large HDL‐P with cIMT measured in the common and internal carotid arteries, through linear regression. After adjustment for CVD confounders, low‐density lipoprotein cholesterol (LDL‐C), HDL‐C, and small+medium HDL‐P remained significantly and inversely associated with common (coefficient=−1.46 μm; P =0.00037; n=6512) and internal cIMT (coefficient=−3.82 μm; P =0.0051; n=6418) after Bonferroni correction for 4 independent tests (threshold for significance=0.0125; α=0.05/4). Large HDL‐P was significantly and inversely associated with both cIMT outcomes before HDL‐C adjustment; however, after adjustment for HDL‐C, the association of large HDL‐P with both common (coefficient=1.55 μm; P =0.30; n=6512) and internal cIMT (coefficient=4.84 μm; P =0.33; n=6418) was attenuated. In a separate sample of 126 men, small/medium HDL‐P was more strongly correlated with paraoxonase 1 activity ( r p =0.32; P =0.00023) as compared to both total HDL‐P ( r p =0.27; P =0.0024) and large HDL‐P ( r p =0.02; P =0.41) measures. Conclusions: Small+medium HDL‐P is significantly and inversely correlated with cIMT measurements. Correlation of small+medium HDL‐P with cardioprotective paraoxonase 1 activity may reflect a functional aspect of HDL responsible for this finding.