A pilot trial of square biphasic pulse deep brain stimulation for dystonia: The BIP dystonia study. Issue 4 (13th February 2017)

• Record Type: Journal Article
• Authors: Almeida, Leonardo; Martinez‐Ramirez, Daniel; Ahmed, Bilal; Deeb, Wissam; Jesus, Sol De; Skinner, Jared; Terza, Matthew J.; Akbar, Umer; Raike, Robert S.; Hass, Chris J.; Okun, Michael S.
• Is Part Of: Movement disorders. Volume 32:Issue 4(2017)
• Page Start: 615
• Page End: 618
• Publication Date: 2017-02-13
• Subjects: dystonia -- deep brain stimulation -- square biphasic stimulation; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26906
• Languages: English
• ISSNs: 0885-3185

Abstract

ABSTRACT: Background : Dystonia often has inconsistent benefits and requires more energy‐demanding DBS settings. Studies suggest that squared biphasic pulses could provide significant clinical benefit; however, dystonia patients have not been explored. Objectives : To assess safety and tolerability of square biphasic DBS in dystonia patients. Methods : This study included primary generalized or cervical dystonia patients with bilateral GPi DBS. Square biphasic pulses were implemented and patients were assessed at baseline, immediately postwashout, post–30‐minute washout, 1 hour post‐ and 2 hours postinitiation of investigational settings. Results : Ten participants completed the study. There were no patient‐reported or clinician‐observed side effects. There was improvement across time on the Toronto Western Spasmodic Torticollis Rating Scale (χ 2 = 10.7; P = 0.031). Similar improvement was detected in objective gait measurements. Conclusions : Square biphasic stimulation appears safe and feasible in dystonia patients with GPi DBS. Further studies are needed to evaluate possible effectiveness particularly in cervical and gait features. © 2016 International Parkinson and Movement Disorder Society