Diffuse cerebral vasospasm with infarct after intrathecal cytarabine in childhood leukemia. Issue 6 (18th December 2014)

• Record Type: Journal Article
• Authors: Yoon, Jong Hyung; Yoon, Ju Young; Park, Hyeon Jin; Son, Meong Hi; Kim, Su‐Hyun; Kim, Woojun; Kim, Ho Jin; Lee, Sang Hyun; Park, Byung‐Kiu
• Is Part Of: Pediatrics international. Volume 56:Issue 6(2014)
• Page Start: 921
• Page End: 924
• Publication Date: 2014-12-18
• Subjects: acute lymphoblastic leukemia -- cerebral vasospasm -- intrathecal cytarabine; Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.12394
• Languages: English
• ISSNs: 1328-8067

Abstract

Abstract: Although the varied neurotoxicity of intrathecal (IT) chemotherapy for treatment of childhood acute leukemia is well known, most are related to transient post‐puncture headache, drug‐induced arachnoiditis, or leukoencephalopathy after methotrexate or cytarabine. Cerebral vasospasm leading to acute infarct after IT chemotherapy is very uncommon in children. Reported herein is a rare case of diffuse cerebral vasospasm with subsequent cerebral infarct after IT cytarabine in a 7‐year‐old boy with acute lymphoblastic leukemia, who successfully recovered with supportive management, and a review of the literature.