Angupyrones A – E, α‐Pyrone Analogues with ARE‐Activation from a Sponge‐Associated Fungus Truncatella angustata. Issue 9 (18th August 2017)

• Record Type: Journal Article
• Authors: Zhao, Yang; Liu, Dong; Proksch, Peter; Yu, Siwang; Lin, Wenhan
• Is Part Of: Chemistry & biodiversity. Volume 14:Issue 9(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-08-18
• Subjects: Fungus -- Truncatella angustata -- Angupyrones A – E -- Structure elucidation -- ARE activation; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201700236
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : TLC‐DPPH guided fractionation of a sponge‐associated fungus Truncatella angustata with a solid culture resulted in the isolation of five new α ‐pyrone‐based analogues namely angupyrones A – E (1 – 5 ), and 3‐ethyl‐4‐hydroxy‐6‐methyl‐2‐pyrone. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher 's method, bulkiness rule, and specific rotation for the configurational assignments. Angupyrones A – E exhibited moderate antioxidant response element activation in HepG2C8 cells, while the preliminary structure‐activity relationship was discussed. Abstract :