Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy. (3rd March 2016)

• Record Type: Journal Article
• Authors: Cubillos-Ruiz, Juan R.; Glimcher, Laurie H.
• Is Part Of: Oncoimmunology. Volume 5:Number 3(2016)
• Publication Date: 2016-03-03
• Subjects: Cancer immunotherapy -- dendritic cells -- IRE1 -- tumor immunology -- tumor microenvironment -- XBP1; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2015.1098802
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Cancers thrive under adverse conditions and simultaneously inhibit antitumor immunity. We recently found that endoplasmic reticulum (ER) stress responses driven by the IRE1α-XBP1 pathway not only promote cancer cell survival, but also provoke severe dendritic cell (DC) dysfunction in tumors. Targeting IRE1α-XBP1 represents a two-pronged approach to restrain malignant cells while eliciting concomitant antitumor immunity.