Strategies to accelerate immune recovery after allogeneic hematopoietic stem cell transplantation. (3rd March 2016)

• Record Type: Journal Article
• Authors: Lucarelli, Barbarella; Merli, Pietro; Bertaina, Valentina; Locatelli, Franco
• Is Part Of: Expert review of clinical immunology. Volume 12:Number 3(2016)
• Page Start: 343
• Page End: 358
• Publication Date: 2016-03-03
• Subjects: Immune reconstitution -- hematopoietic stem cell transplantation -- donor leukocyte infusion -- thymus function -- T-cell immunotherapy; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1586/1744666X.2016.1123091
• Languages: English
• ISSNs: 1744-666X

Abstract

ABSTRACT: The interplay existing between immune reconstitution and patient outcome has been extensively demonstrated in allogeneic hematopoietic stem cell transplantation. One of the leading causes of infection-related mortality is the slow recovery of T-cell immunity due to the conditioning regimen and/or age-related thymus damage, poor naïve T-cell output, and restricted T-cell receptor (TCR) repertoires. With the aim of improving posttransplantation immune reconstitution, several immunotherapy approaches have been explored. Donor leukocyte infusions are widely used to accelerate immune recovery, but they carry the risk of provoking graft-versus-host disease. This review will focus on sophisticated strategies of thymus function-recovery, adoptive infusion of donor-derived, allodepleted T cells, T-cell lines/clones specific for life-threatening pathogens, regulatory T cells, and of T cells transduced with suicide genes.