Metal-free diastereoselective construction of bridged ketal spirooxindoles via a Michael addition-inspired sequence. Issue 81 (28th September 2017)

• Record Type: Journal Article
• Authors: Zhu, Yanshuo; Zhou, Jing; Jin, Shaojing; Dong, Huahui; Guo, Jiaomei; Bai, Xuguan; Wang, Qilin; Bu, Zhanwei
• Is Part Of: Chemical communications. Volume 53:Issue 81(2017)
• Page Start: 11201
• Page End: 11204
• Publication Date: 2017-09-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc05813f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A TfOH-catalyzed highly diastereoselective Michael addition/ketalization sequence of 3-hydroxyoxindoles and ortho -hydroxychalcones was developed, leading to biologically important bridged ketal spirooxindoles in moderate to excellent yields. Abstract : A TfOH-catalyzed highly diastereoselective Michael addition/ketalization sequence of 3-hydroxyoxindoles and ortho -hydroxychalcones was developed, leading to biologically important bridged ketal spirooxindoles in moderate to excellent yields. Moreover, some chemical transformations were carried out to further extend the structural complexity and diversity.