Turning on the red phosphorescence of a [Ru(tpy)(bpy)(Cl)]Cl complex by amide substitution: self-aggregation, toxicity, and cellular localization of an emissive ruthenium-based amphiphile. Issue 81 (6th July 2017)

• Record Type: Journal Article
• Authors: Siewert, B.; Langerman, M.; Hontani, Y.; Kennis, J. T. M.; van Rixel, V. H. S.; Limburg, B.; Siegler, M. A.; Talens Saez, V.; Kieltyka, R. E.; Bonnet, S.
• Is Part Of: Chemical communications. Volume 53:Issue 81(2017)
• Page Start: 11126
• Page End: 11129
• Publication Date: 2017-07-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc02989f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Dodecylamide functionalization of [Ru(tpy)(bpy)Cl]Cl led to an emissive, self-assembling, and cytotoxic complex targeting membranes. Abstract : Coupling the notoriously non-emissive complex [Ru(tpy)(bpy)Cl]Cl (tpy = 2, 2′:6′, 2′′-terpyridine, bpy = 2, 2′-bipyridine) to a C12 alkyl chain via an amide linker on the 4′ position of the terpyridine yielded a new amphiphilic ruthenium complex showing red emission and chloride-dependent aggregation properties. This emissive complex is highly cytotoxic in A549 non-small lung cancer cells where it can be followed by confocal microscopy. Uptake occurs within minutes, first by insertion into the cellular membrane, and then by migration to the peri-nuclear region.