C(sp3)–H amination of 8-methylquinolines with azodicarboxylates under Rh(iii) catalysis: cytotoxic evaluation of quinolin-8-ylmethanamines. Issue 81 (28th September 2017)

• Record Type: Journal Article
• Authors: Jeong, Taejoo; Mishra, Neeraj Kumar; Dey, Prasanta; Oh, Hyunjung; Han, Sangil; Lee, Suk Hun; Kim, Hyung Sik; Park, Jihye; Kim, In Su
• Is Part Of: Chemical communications. Volume 53:Issue 81(2017)
• Page Start: 11197
• Page End: 11200
• Publication Date: 2017-09-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc06670h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The rhodium(iii )-catalyzed C(sp 3 )–H amination reaction of 8-methylquinolines and azodicarboxylates is described for the construction of quinolin-8-ylmethanamine derivatives, which were evaluated for in vitro cytotoxicity. Abstract : The rhodium(iii )-catalyzed C(sp 3 )–H amination reaction of 8-methylquinolines and azodicarboxylates is described. A cationic rhodium catalyst in the presence of lithium acetate and lithium carbonate was found to be an optimal catalytic system for the construction of quinolin-8-ylmethanamine derivatives, which were evaluated for in vitro cytotoxicity against human breast adenocarcinoma cells (MCF-7) and human prostate adenocarcinoma cells (LNCaP).