Corneal Higher-Order Aberrations in Herpes Simplex Keratitis. Issue 12 (December 2016)

• Record Type: Journal Article
• Authors: Kashizuka, Emi; Yamaguchi, Takefumi; Yaguchi, Yukari; Satake, Yoshiyuki; Shimazaki, Jun
• Is Part Of: Cornea. Volume 35:Issue 12(2016)
• Publication Date: 2016-12
• Subjects: herpetic keratitis -- corneal opacity -- higher-order aberration -- visual acuity; Cornea -- Periodicals; Cornea -- Periodicals; Cornée -- Périodiques; 617.719
• DOI: 10.1097/ICO.0000000000000910
• Languages: English
• ISSNs: 0277-3740

Abstract

Abstract : Purpose: To evaluate corneal higher-order aberrations (HOAs) in eyes with corneal scars due to herpes simplex keratitis (HSK). Methods: Forty-four eyes of 41 consecutive patients who were diagnosed with corneal scars due to HSK and 18 control eyes were included. HOAs of the anterior and posterior surfaces and the total cornea were analyzed using anterior segment optical coherence tomography. Corneal opacity grades were assigned on the basis of slit-lamp examinations. Results: HOAs within a 4-mm diameter were significantly larger in eyes with HSK (anterior surface, 1.01 ± 1.18 μm; posterior surface, 0.25 ± 0.24; total cornea, 1.00 ± 1.00) compared with controls (0.10 ± 0.02, 0.02 ± 0.00, and 0.09 ± 0.01, respectively; all P < 0.001). HOAs within a 6-mm diameter were significantly larger in eyes with HSK (anterior surface, 1.87 ± 1.75; posterior surface, 0.42 ± 0.44; total cornea, 1.85 ± 1.46) compared with controls (0.19 ± 0.04, 0.06 ± 0.01, and 0.17 ± 0.03, respectively; all, P < 0.001). The logarithm of the minimum angle of resolution (logMAR) decreased with the corneal opacity score (0.42 ± 0.61 in grade 1, 1.30 ± 0.96 in grade 2, and 1.58 ± 0.90 in grade 3). LogMAR was significantly correlated with HOAs (R = 0.65, P < 0.0001). HOAs of the posterior surface increased from 0.15 ± 0.15 in grade 1 to 0.37 ± 0.33 in grade 3 ( P = 0.005), whereas there was no difference in HOAs of the anterior surface and the total cornea among the different corneal opacity grades. Conclusions: Increased HOAs of the anterior and posterior surfaces occur in eyes with corneal opacity due to HSK. Larger corneal HOAs are associated with poorer visual acuity.