Cutaneous Malignant Melanoma With Rhabdoid Morphology and Smooth Muscle Differentiation: A Challenging Histopathologic Diagnosis. (May 2017)

• Record Type: Journal Article
• Authors: Prieto-Torres, Lucía; Alegría-Landa, Victoria; Llanos, Concepción; Córdoba, Alicia; Kutzner, Heinz; Requena, Luis
• Is Part Of: American journal of dermatopathology. Volume 39:Number 5(2017)
• Publication Date: 2017-05
• Subjects: malignant melanoma -- divergent differentiation -- rhabdomyosarcomatous differentiation -- rhabdoid melanoma -- smooth muscle differentiation; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000000792
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: Divergent differentiation or metaplastic change is a rare feature exhibited occasionally in malignant melanoma (MM), which is characterized by the development of morphologically, immunochemically, and/or ultrastructurally nonmelanocytic cells within the tumor. Smooth muscle differentiation in MM is an exceedingly rare phenomenon reported only in a few cases in the literature. We report the case of a 69-year-old woman who presented with a pure dermal amelanotic MM with smooth muscle cell differentiation and an area of rhabdoid morphology, which made the accurate histopathologic diagnostic of MM challenging.