Extrauterine Placental Site Trophoblastic Tumor Involving the Vagina. (May 2017)

• Record Type: Journal Article
• Authors: Gupta, Mayank; Gnanasekaran, Kiruthiga K.; Manojkumar, Ramani; Thomas, Anitha; Sebastian, Ajit
• Is Part Of: International journal of gynecological pathology. Volume 36:Number 3(2017)
• Publication Date: 2017-05
• Subjects: Placental Site Trophoblastic Tumor -- Epithelioid Trophoblastic Tumor -- Choriocarcinoma; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000318
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Very few cases of placental site trophoblastic tumor (PSTT) primarily involving extrauterine sites have been reported to date. We report a case of a 29-year-old female who presented with a vaginal nodule 9 months after delivery at an outside hospital which was initially diagnosed as a poorly differentiated squamous cell carcinoma. Subsequently she was referred to our institute, and on the basis of histology, mildly elevated serum β-HCG level, and immunohistochemistry, PSTT was diagnosed. After the completion of chemotherapy, the vaginal nodule completely regressed and serum β-hCG returned to baseline. Her follow-up has been unremarkable. This case highlights the importance of the fact that PSTT can be easily misdiagnosed at extrauterine sites in the absence of proper clinical, histologic, and immunohistochemical correlation.