Vitamin D Receptor (VDR) Polymorphisms in Pediatric Patients Presenting With Hodgkin's Lymphoma. Issue 2 (March 2017)

• Record Type: Journal Article
• Authors: Tekgündüz, Sibel A.; Yeşil, Şule; Ören, Ayşe C.; Tanyildiz, Hikmet G.; Çandir, Mehmet O.; Bozkurt, Ceyhun; Şahin, Gürses
• Is Part Of: Journal of pediatric hematology/oncology. Volume 39:Issue 2(2017)
• Publication Date: 2017-03
• Subjects: vitamin D receptor -- Hodgkin's lymphoma -- polymorphisms; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000664
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Vitamin D receptor (VDR) polymorphisms are found more commonly in some tumor types than in healthy individuals, suggesting that some polymorphisms (Cdx2, Fok1, Bsm1, Apa1, Taq1) contribute to tumor development. There is no previous report on VDR polymorphism in Hodgkin's lymphoma (HL) patients. VDR polymorphism patterns in 95 pediatric HL cases with 100 healthy controls were compared. No statistically significant difference was found between the patient group and control group in terms of Cdx2, Fok1, Bsm1, Apa1, and Taq1 polymorphisms ( P >0.5). Our findings suggest that VDR polymorphisms may not play a role in HL development.