An Uncommon Complication With Use of Topical Local Anesthetic Agents: Methemoglobinemia. (November 2016)

• Record Type: Journal Article
• Authors: Panikkath, Ragesh; Panikkath, Deepa; Wischmeyer, Jason
• Is Part Of: American journal of therapeutics. Volume 23:Number 6(2016)
• Publication Date: 2016-11
• Subjects: local anesthetics -- methemoglobinemia -- transesophageal echocardiography -- complication -- dyspnea; Chemotherapy -- Periodicals; Pharmacology -- Periodicals; 615.58
• DOI: 10.1097/MJT.0000000000000355
• Languages: English
• ISSNs: 1075-2765

Abstract

Abstract : Although the use of topical local anesthetics is generally safe, several potentially fatal complications have been reported. Methemoglobinemia is a rare but potentially fatal complication. Methemoglobin is a naturally occurring oxidized metabolite of hemoglobin, and physiologic levels (<1%) are normal. Methemoglobinemia can be congenital or acquired. Several drugs including topical anesthetic agents like benzocaine can induce this condition. Sudden appearance of cyanosis, with a disproportionately better oxygen saturation of 85% after use of local anesthetics can be a helpful for diagnosis.