Ischemic Conditioning Attenuates Platelet-Mediated Thrombosis: A Tale of Reverse Translation. (September 2017)

• Record Type: Journal Article
• Authors: Przyklenk, Karin; Whittaker, Peter
• Other Names: Przyklenk Karin guest-editor.; Whittaker Peter guest-editor.
• Is Part Of: Journal of cardiovascular pharmacology and therapeutics. Volume 22:Number 5(2017:Sep.)
• Page Start: 391
• Page End: 396
• Publication Date: 2017-09
• Subjects: ischemic preconditioning -- remote ischemic conditioning -- platelet -- thrombosis -- P-selectin -- monocyte–platelet aggregates -- neutrophil–platelet aggregates; Cardiovascular pharmacology -- Periodicals; Cardiovascular system -- Diseases -- Treatment -- Periodicals; 616
• DOI: 10.1177/1074248417724871
• Languages: English
• ISSNs: 1074-2484

Abstract

Data obtained in both preclinical models and humans have revealed that the favorable cardiac consequences of ischemic conditioning extend beyond a direct effect on the cardiomyocyte. In the current review, we summarize our as-yet limited understanding of the complex relationships between ischemic conditioning, platelet activation–aggregation, and cardioprotection.