Image-Guided Adaptive Radiation Therapy with anatomic imaging and dose verification in head and neck cancer using kV CBCT. (29th March 2012)

• Record Type: Journal Article
• Authors: Chan, Maria F.; Song, Yulin; Burman, Chandra; Hu, Yu-Chi; Sim, Sang E.
• Is Part Of: International journal of biomedical engineering and technology. Volume 8:Number 2/3(2012)
• Page Start: 151
• Page End: 166
• Publication Date: 2012-03-29
• Subjects: IGRT -- image-guided radiation therapy -- IMRT -- intensity-modulated radiation therapy -- adaptive radiation therapy -- kV cone-beam CT -- 4DRT -- 4-dimensional radiation therapy -- head and neck cancer; Biomedical engineering -- Periodicals; 610.28
• Languages: English
• ISSNs: 1752-6418

Abstract

Image-Guided Adaptive Radiation Therapy (IGART) is a promising approach in radiotherapy for bulky head-and-neck tumours. We have developed a methodology for dosimetric replanning using kV-CBCT. A case study is presented in which the CBCT and planning CT (pCT) images were registered to generate Adaptive pCT (ApCT). The registration similarity measure was intensity-based 'Mutual Information'. The search was optimised using the 'downhill simplex' algorithm. Dose-distribution and DVH were re-calculated. The actual dose delivered can be assessed based on the ApCT. Clinical implementation of IGART has potential to compensate for inter-fractional changes, while reducing damage to critical organs and increasing tumour targeting.