PEDOT:PSS: A Conductive and Flexible Polymer for Sensor Integration in Organ-on-Chip Platforms. (2016)

• Record Type: Journal Article
• Authors: Quirós-Solano, W.F.; Gaio, N.; Silvestri, C.; Pandraud, G.; Sarro, P.M.
• Is Part Of: Procedia engineering. Volume 168(2016)
• Page Start: 1184
• Page End: 1187
• Publication Date: 2016
• Subjects: Organ-on-Chip -- Sensing -- PDMS -- Membrane -- Cell -- Microenvironment -- Heart-on-Chip; Engineering -- Congresses; Engineering -- Periodicals; Engineering; Conference proceedings; Periodicals; 620.005
• DOI: 10.1016/j.proeng.2016.11.401
• Languages: English
• ISSNs: 1877-7058

Abstract

Abstract: Sensing and stimulating microstructures are necessary to develop more specialized and highly accurate Organ-on-Chip (OOC) platforms. In this paper, we present the integration of a conductive polymer, poly (3, 4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), on a stretchable membrane, core element of an Heart-on-Chip. The electrical conductivity along with its biocompatibility, high transparency (≈88%) and mechanical elasticity (≈1.2 GPa) make this material a candidate to develop novel microstructures for electrical monitoring and stimulation of cells in flexible-substrate based OOCs. Microstructures with different shapes and geometries of PEDOT:PSS embedded in a 9 μm-thick Polydimethylsiloxane (PDMS) membrane are developed following a wafer-level fabrication approach. PEDOT:PSS layers between 120 nm and 300 nm are obtained by varying the deposition conditions. The layers are successfully patterned and microstructures with lateral dimensions down to 2 μm. The obtained results indicate that this polymer is a suitable material for microfabrication of sensing and stimulating elements in OOC platforms.