Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells. Issue 9 (1st May 2015)

• Record Type: Journal Article
• Authors: Lee, Dahae; Kim, Ki Hyun; Moon, Sung Won; Lee, Heesu; Kang, Ki Sung; Lee, Jae Wook
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 9(2015)
• Page Start: 1929
• Page End: 1932
• Publication Date: 2015-05-01
• Subjects: Chalcone -- Cisplatin-induced nephrotoxicity -- Renoprotection -- MAPKs-p53-caspase-3; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.03.026
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.