Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives. Issue 2 (15th January 2015)

• Record Type: Journal Article
• Authors: Yamamuro, Daisuke; Uchida, Ryuji; Ohtawa, Masaki; Arima, Shiho; Futamura, Yushi; Katane, Masumi; Homma, Hiroshi; Nagamitsu, Tohru; Osada, Hiroyuki; Tomoda, Hiroshi
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 2(2015)
• Page Start: 313
• Page End: 316
• Publication Date: 2015-01-15
• Subjects: 5-(4′-Methoxyphenyl)-oxazole -- Caenorhabditis elegans -- Hatch inhibition; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2014.11.042
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: 5-(4′-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti- C. elegans activity.