Modified calanolides incorporated with furan-2-nitro mimics against Mycobacterium tuberculosis. Issue 6 (15th March 2015)

• Record Type: Journal Article
• Authors: Liu, Zijie; Guo, Xiaoyong; Liu, Gang
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 6(2015)
• Page Start: 1297
• Page End: 1300
• Publication Date: 2015-03-15
• Subjects: Mycobacterium tuberculosis -- (+)-Calanolide A -- Nature product -- Benzofuran; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.01.046
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: (+)-Calanolide A was identified as an active agent against both HIV-1 and Mycobacterium tuberculosis ( Mtb ). We modified Ring D of calanolide compounds with furan-2-nitro mimics and obtained 15 compounds. After in vitro tests, two compounds were shown to be active against replicating (R) Mtb, but not against non-replicating (NR) Mtb . Further optimization for potent candidates against both R Mtb and NR Mtb will result from this research.