Facile and diastereoselective synthesis of 3, 2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities. Issue 2 (15th January 2015)

• Record Type: Journal Article
• Authors: Kathirvelan, D.; Haribabu, J.; Reddy, B.S.R.; Balachandran, C.; Duraipandiyan, V.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 2(2015)
• Page Start: 389
• Page End: 399
• Publication Date: 2015-01-15
• Subjects: Multicomponent reaction -- Spirooxindole -- Pyrazole moiety -- Antimicrobial activity -- Molecular docking; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2014.10.099
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: In the present study, a series of novel highly functionalized spiropyrrolidine–oxindoles have been synthesized through 1, 3-dipolar cycloaddition of an azomethine ylide formed from isatin and various amino acids such as sarcosine, proline and thioproline with the dipolarophile ( E )-3-(1, 3-diphenyl-1H-pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile under optimized conditions. All the synthesized compounds were evaluated for their antimicrobial activity and shown significant activity.