Lactate retards the development of erythrocytic stages of the human malaria parasite Plasmodium falciparum. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Hikosaka, Kenji; Hirai, Makoto; Komatsuya, Keisuke; Ono, Yasuo; Kita, Kiyoshi
• Is Part Of: Parasitology international. Volume 64:Issue 3(2015:Jun.)
• Page Start: 301
• Page End: 303
• Publication Date: 2015-06
• Subjects: Malaria -- Plasmodium -- Lactate -- In vitro culture -- Developmental retardation; Parasitology -- Periodicals; Parasites -- Periodicals; Parasitic Diseases -- Periodicals; Parasitology -- Periodicals; Parasitologie -- Périodiques; 571.99905
• DOI: 10.1016/j.parint.2014.08.003
• Languages: English
• ISSNs: 1383-5769

Abstract

Abstract: The intraerythrocytic form of the human malaria parasite Plasmodium falciparum relies on glycolysis for its energy requirements. In glycolysis, lactate is an end product. It is therefore known that lactate accumulates in in vitro culture; however, its influence on parasite growth remains unknown. Here we investigated the effect of lactate on the development of P. falciparum during in vitro culture under lactate supplementation in detail. Results revealed that lactate retarded parasite development and reduced the number of merozoites in the schizont stage. These findings suggest that lactate has the potential to affect parasite development. Graphical abstract: Highlights: Plasmodium falciparum relies on glycolysis for its energy requirements. Lactate is an end product of glycolysis and accumulates in parasite culture in vitro . Lactate retards malaria parasite development and reduces the number of merozoites.