A unifying experimental design for dissecting tree genomes. (August 2015)

• Record Type: Journal Article
• Authors: Sun, Lidan; Zhu, Xuli; Zhang, Qixiang; Wu, Rongling
• Is Part Of: Trends in plant science. Volume 20:Number 8(2015)
• Page Start: 473
• Page End: 476
• Publication Date: 2015-08
• Subjects: Botany -- Periodicals; Botanique -- Périodiques; Botany; Periodicals; 580.5
• DOI: 10.1016/j.tplants.2015.05.012
• Languages: English
• ISSNs: 1360-1385

Abstract

Highlights: Linkage mapping and association analysis are used separately, limiting their potential power. We integrate these two approaches into an organizing framework through an open-pollinated design. The integrative model strengthens population and quantitative genetic studies for evolutionary inference and high-resolution gene mapping. The design particularly suits genome dissection of forest trees given their undomesticated populations. Abstract : Linkage mapping and association mapping are adopted as an approach of choice for dissecting complex traits, but each shows a limitation when used alone. We propose an open-pollinated (OP) family design to integrate these two approaches into an organizing framework. The design unifies the strengths of population and quantitative genetic studies for evolutionary inference and high-resolution gene mapping. It particularly suits genome dissection of forest trees given their extant populations that are mostly undomesticated.