The effects of ovariectomy and LPS-induced endotoxemia on resistin levels in female rats. Issue 2 (December 2015)

• Record Type: Journal Article
• Authors: Iwasa, Takeshi; Matsuzaki, Toshiya; Matsui, Sumika; Tungalagsuvd, Altankhuu; Munkhzaya, Munkhsaikhan; Kawami, Takako; Yamasaki, Mikio; Murakami, Masahiro; Kato, Takeshi; Kuwahara, Akira; Yasui, Toshiyuki; Irahara, Minoru
• Is Part Of: Cytokine. Volume 76:Issue 2(2015)
• Page Start: 558
• Page End: 560
• Publication Date: 2015-12
• Subjects: Resistin -- Ovary -- OVX -- LPS; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.06.003
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: We investigated the responses of resistin to LPS in rats. OVX rats showed increased serum resistin level and adipose resistin mRNA level compared with sham-operated female rats. Resistin levels in OVX rats were similar to those in male rats. Under LPS-injected condition, resistin levels in OVX did not differ compared with those in sham-operated rats. Basal resistin levels might be partially controlled by ovarian hormones. Abstract: Resistin is involved in the inflammatory response, as well as in insulin resistance. In rodents, resistin levels are partially regulated by ovarian hormones. Thus, ovariectomy-induced changes in resistin levels and their response to lipopolysaccharide (LPS)-induced septic stress were evaluated. Ovariectomized (OVX) rats exhibited higher serum resistin concentrations and visceral and subcutaneous white adipose tissue (WAT) resistin mRNA levels than sham-operated (sham) rats under the saline-injected (basal) conditions. The serum resistin levels of the gonadal intact male rats were higher than those of the sham rats, whereas the serum resistin levels of the male and OVX rats did not differ. In both the sham and OVX rats, the serum resistin concentration and the resistin mRNA levels of WAT were increased by LPS injection. At 24 h after the LPS injection, no difference was detected in the serum resistin concentrations or WAT mRNA resistin levels between the sham and OVX rats. These results suggest that ovarian hormones partially regulate the basal resistin levels of female rats.