Automated auditory brainstem response in preterm newborns with histological chorioamnionitis. (6th November 2014)

• Record Type: Journal Article
• Authors: Smit, Adriana L.; Been, Jasper V.; Zimmermann, Luc J. I.; Kornelisse, Rene F.; Andriessen, Peter; Vanterpool, Sizzle F.; Bischoff, Martijn P. H.; Stokroos, Robert J.; de Krijger, Ronald R.; Kremer, Bernd; Kramer, Boris W.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 28:Number 15(2015)
• Page Start: 1864
• Page End: 1869
• Publication Date: 2014-11-06
• Subjects: Automated auditory brainstem response -- chorioamnionitis -- hearing screening -- preterm infants; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. Methods : Two cohorts of very preterm newborns ( n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. Results : In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 – 3.8, p = 0.54 and OR 1.1, 95% CI 0.4–3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0–0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5–0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2–11.6, p = 0.03). Conclusions : Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.