Functional outcome of macular edema in different retinal disorders. (September 2015)

• Record Type: Journal Article
• Authors: Tomkins-Netzer, Oren; Ismetova, Filis; Bar, Asaf; Seguin-Greenstein, Sophie; Kramer, Michal; Lightman, Sue
• Is Part Of: Progress in retinal and eye research. Volume 48(2015:Sep.)
• Page Start: 119
• Page End: 136
• Publication Date: 2015-09
• Subjects: Macular edema -- Best corrected visual acuity -- Retinal contrast sensitivity -- Microperimetry -- Reading speed -- Vision loss; BRB blood-retinal barrier -- FFA fluorescein angiography -- OCT optical coherence tomography -- VEGF vascular endothelial growth factor -- RVO retinal vein occlusion -- UCVA uncorrected visual acuity -- BCVA best corrected visual acuity -- LogMAR logarithmic minimal acuity of resolution -- ETDRS early treatment diabetic retinopathy study -- MNREAD Minnesota Near Reading Test -- DME diabetic macular edema -- CSME clinically significant macular edema -- SD-OCT spectral domain-optical coherence tomography -- CRVO central retinal vein occlusion -- BRVO branch retinal vein occlusion -- TNF tumor necrosis factor -- Tregs regulatory T cells -- TGF-β Tumor growth factor beta -- ELM external limiting membrane -- IVTA intravitreal triamcinolone acetate -- APMPPE acute posterior multifocal placoid pigment epitheliopathy -- VKH Vogt-Koyanagi-Harada -- SEM standard error of the mean -- PPV pars plana vitrectomy; Retina -- Periodicals; Retina -- Research -- Methodology -- Periodicals; Eye -- Diseases -- Periodicals; Eye -- Periodicals; Eye Diseases -- Periodicals; Retina -- Periodicals; Rétine -- Périodiques; Rétine -- Recherche -- Méthodologie -- Périodiques; 617.7005
• DOI: 10.1016/j.preteyeres.2015.05.002
• Languages: English
• ISSNs: 1350-9462

Abstract

Abstract: Macular edema accompanies many ocular pathologies, affecting visual function and is an important factor in treatment decisions and disease outcome. Though visual acuity is commonly used to evaluate patient vision it does not always provide a complete estimate of their visual abilities or reflect their own visual perception. Furthermore, different pathologies result in macular edema causing a variable effect on visual function, related to the rate of fluid accumulation and accompanying ocular changes. Use of complementary visual function tests, such as retinal contrast sensitivity on microperimetry and reading speed provide additional information that can be used to evaluate patients and assist in treatment choices. Here we explore the effect of macular edema on visual function in different retinal pathologies, namely diabetic retinopathy, retinal vein occlusion and uveitis, examine its influence on the various vision tests and discuss the factors underlying this variable response. Graphical abstract: