Risk science in the 21st century: a data-driven framework for incorporating new technologies into chemical safety assessment. (2017)

• Record Type: Journal Article
• Authors: Thomas, Russell S.; Cheung, Ricky; Westphal, Margit; Krewski, Daniel; Andersen, Melvin E.
• Is Part Of: International journal of risk assessment and management. Volume 20:Number 1/2/3 (2017)
• Page Start: 88
• Page End: 108
• Publication Date: 2017
• Subjects: risk assessment -- chemical safety assessment -- margin of exposure -- MOE -- tiered approach -- predictive toxicology -- risk science -- safe chemicals -- new technologies -- high throughput screening -- HTS -- in vitro assay platforms -- biological omics assays -- molecular biomarkers -- quantitative structure activity relationship -- QSAR modelling -- in vitro to in vivo extrapolation -- IVIVE -- physiologically-based pharmacokinetics -- PBPK modelling -- functional genomics -- bioinformatics -- computational biology; Risk assessment -- Periodicals; Risk management -- Periodicals; 361.1
• Languages: English
• ISSNs: 1466-8297

Abstract

One of the major challenges in chemical safety assessment is prioritisation of the large number of chemicals in commerce. Over the past five years, a new tiered approach to chemical safety assessment that uses margin of exposure (MOE) as the metric for determining the level of testing required, identifies chemicals of greatest concern. This paper evaluates the role of new technologies and novel tools in improving different steps of chemical risk assessment processes such as high throughput screening (HTS) in vitro assay platforms, high content biological omics assays, molecular biomarkers, quantitative structure activity relationship (QSAR) modelling, in vitro to in vivo extrapolation (IVIVE) and physiologically-based pharmacokinetic (PBPK) modelling. Other technologies such as functional genomics, bioinformatics, and computational biology can expedite the analysis. This new approach could potentially be used to prioritise and categorise chemicals on the domestic substance list (DSL) under the Canadian Environmental Protection Act (CEPA).