Performance of shear-wave elastography for breast masses using different region-of-interest (ROI) settings. (July 2018)

• Record Type: Journal Article
• Authors: Youk, Ji Hyun; Son, Eun Ju; Han, Kyunghwa; Gweon, Hye Mi; Kim, Jeong-Ah
• Is Part Of: Acta radiologica. Volume 59:Number 7(2018:Sep.)
• Page Start: 789
• Page End: 797
• Publication Date: 2018-07
• Subjects: Breast cancer -- ultrasonography -- sonoelastography -- shear wave -- diagnostic performance; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185117735562
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: Various size and shape of region of interest (ROI) can be applied for shear-wave elastography (SWE). Purpose: To investigate the diagnostic performance of SWE according to ROI settings for breast masses. Material and Methods: To measure elasticity for 142 lesions, ROIs were set as follows: circular ROIs 1 mm (ROI-1), 2 mm (ROI-2), and 3 mm (ROI-3) in diameter placed over the stiffest part of the mass; freehand ROIs drawn by tracing the border of mass (ROI-M) and the area of peritumoral increased stiffness (ROI-MR); and circular ROIs placed within the mass (ROI-C) and to encompass the area of peritumoral increased stiffness (ROI-CR). Mean (Emean ), maximum (Emax ), and standard deviation (ESD ) of elasticity values and their areas under the receiver operating characteristic (ROC) curve (AUCs) for diagnostic performance were compared. Results: Means of Emean and ESD significantly differed between ROI-1, ROI-2, and ROI-3 ( P < 0.0001), whereas means of Emax did not ( P = 0.50). For ESD, ROI-1 (0.874) showed a lower AUC than ROI-2 (0.964) and ROI-3 (0.975) ( P < 0.002). The mean ESD was significantly different between ROI-M and ROI-MR and between ROI-C and ROI-CR ( P < 0.0001). The AUCs of ESD in ROI-M and ROI-C were significantly lower than in ROI-MR ( P = 0.041 and 0.015) and ROI-CR ( P = 0.007 and 0.004). Conclusion: Shear-wave elasticity values and their diagnostic performance vary based on ROI settings and elasticity indices. Emax is recommended for the ROIs over the stiffest part of mass and an ROI encompassing the peritumoral area of increased stiffness is recommended for elastic heterogeneity of mass.