Ruthenium(II)‐Catalyzed C−C Arylations and Alkylations: Decarbamoylative C−C Functionalizations. Issue 19 (5th April 2017)

• Record Type: Journal Article
• Authors: Moselage, Marc; Li, Jie; Kramm, Frederik; Ackermann, Lutz
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 19(2017)
• Page Start: 5341
• Page End: 5344
• Publication Date: 2017-04-05
• Subjects: amides -- arylation -- C−C activation -- reaction mechanisms -- ruthenium; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201701231
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Ruthenium(II)biscarboxylate catalysis enabled selective C−C functionalizations by means of decarbamoylative C−C arylations. The versatility of the ruthenium(II) catalysis was reflected by widely applicable C−C arylations and C−C alkylations of aryl amides, as well as acids with modifiable pyrazoles, through facile organometallic C−C activation. Abstract : Amid the methods : Amide σ‐C−C arylations were accomplished by versatile ruthenium(II) carboxylate decarbamoylative catalysis, which enabled decarboxylative ipso C−C alkylations by facile organometallic C−C cleavage. The method is versatile, robust, and mild, and mechanistic insights are discussed.