Resveratrol and cancer treatment: updates. Issue 1 (25th September 2017)

• Record Type: Journal Article
• Authors: Jiang, Zhengdong; Chen, Ke; Cheng, Liang; Yan, Bin; Qian, Weikun; Cao, Junyu; Li, Jie; Wu, Erxi; Ma, Qingyong; Yang, Wei
• Other Names: Vanga Ole guestEditor.; Lin Hung‐Yun guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1403:Issue 1(2017)
• Page Start: 59
• Page End: 69
• Publication Date: 2017-09-25
• Subjects: resveratrol -- cancer therapy -- tumor microenvironment -- cancer stem cells -- chemoradiosensitization; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.13466
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract: Cancer, a growing health problem worldwide, affects millions of people every year. The overall survival rates of most cancers have been prolonged owing to the efforts of clinicians and scientists. However, some tumors develop resistance to chemoradiotherapeutic agents, and the cancer research community continues to search for effective sensitizers. Resveratrol, a natural polyphenolic phytoalexin, has shown promising effects in inhibiting proliferation and cancer progression in several tumor models. However, its molecular mechanisms and applications in chemotherapy and radiotherapy have yet to be fully determined. In this concise review, we highlight the role and related molecular mechanisms of resveratrol in cancer treatment. In particular, we focus on the role of resveratrol in the tumor microenvironment and the sensitization of cancer cells for chemotherapy and radiotherapy. Resveratrol shows promising efficacies in cancer treatment and may be applied in clinical therapy, but it requires further clinical study.